Biological and Medical Applications of Materials and Interfaces
- Peng Zhou
Peng Zhou
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226000, China
More by Peng Zhou
- Mo Wang
Mo Wang
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226000, China
More by Mo Wang
- Tian He
Tian He
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226000, China
More by Tian He
- Ya Cai
Ya Cai
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226000, China
More by Ya Cai
- Yuhang Zhang
Yuhang Zhang
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226000, China
More by Yuhang Zhang
- Guishuan Wang*
Guishuan Wang
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226000, China
See AlsoAccelerating the Catalytic Conversion of Polysulfides in Lithium–Sulfur Batteries from Both the Cathode and the Separator PerspectivesBand Alignment, Thermal Transport Property, and Electrical Performance of High-Quality β-Ga2O3/AlN Schottky Barrier Diode Grown via MOCVDOn the Origin of Temperature Induced Performance Degradation of Cu-Contacted Mg2X-Based (X = Si, Sn) Thermoelectric MaterialsEpitaxial Mixed-Dimensional MoS2 Nanofin-Nanoribbon Hybrids and Their Integration into Electronic and Optoelectronic Devices*Email: [emailprotected]
More by Guishuan Wang
- Fei Sun*
Fei Sun
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226000, China
*Email: [emailprotected];.
More by Fei Sun
- Guoqi Song*
Guoqi Song
Department of Hematology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226000, Jiangsu China
*Email: [emailprotected]
More by Guoqi Song
- Wenqing Li*
Wenqing Li
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226000, China
*Email: [emailprotected]
More by Wenqing Li
Other Access OptionsSupporting Information (1)
ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, 17, 17, 24820–24829
Click to copy citationCitation copied!
https://pubs.acs.org/doi/10.1021/acsami.4c21183
Published April 16, 2025
Publication History
Received
Accepted
Revised
Published
onlinePublished
in issue
research-article
Copyright © 2025 American Chemical Society
Abstract
Click to copy section linkSection link copied!
STING activation is a promising application therapeutic strategy for cancer immunotherapy. In particular, MSA-2 as an oral STING agonist is discovered to have antitumor activity. However, how to improve the antitumor effect of MSA-2 is a very valuable contribution to cancer immunotherapy. Here, we use two strategies to amplify the antitumor effect of MSA-2 by phospholipid nanoparticles delivering STING mRNA and copper-modified MSA-2. We synthesized a new series of ionizable phospholipid nanoparticles and optimized a phospholipid nanoparticle (1AP24) for delivering STING mRNA, increasing the expression of STING protein to bind more MSA-2. Second, we synthesized copper-modified MSA-2 (MSA-2-Cu), which induced cell death by Cu2+ toxicity. Combining 1AP24@STING mRNA and MSA-2-Cu can crucially decrease tumor growth and increase a mouse’s survival. It is a new treatment strategy through amplifying the STING pathway.
ACS Publications
Copyright © 2025 American Chemical Society
Subjects
what are subjects
Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article.
- Cells
- Lipids
- Nanoparticles
- Rodent models
- Tumors
Keywords
what are keywords
Article keywords are supplied by the authors and highlight key terms and topics of the paper.
Read this article
To access this article, please review the available access options below.
Get instant access
Purchase Access
Read this article for 48 hours. Check out below using your ACS ID or as a guest.
Recommended
Access through Your Institution
You may have access to this article through your institution.
Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.
Recommended
Log in to Access
You may have access to this article with your ACS ID if you have previously purchased it or have ACS member benefits. Log in below.
-
Purchase access
Purchase this article for 48 hours $48.00 Add to cart Purchase this article for 48 hours Checkout
Cited By
Click to copy section linkSection link copied!
This article has not yet been cited by other publications.
Download PDF
Get e-Alerts
Get e-Alerts
ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, 17, 17, 24820–24829
Click to copy citationCitation copied!
Published April 16, 2025
Publication History
Received
Accepted
Revised
Published
onlinePublished
in issue
Copyright © 2025 American Chemical Society
Request reuse permissions
Article Views
160
Altmetric
-
Citations
-
Learn about these metrics
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.
